Endocrine Abstracts

Abstract: A 55-year-old woman was admitted to our hospital due to severe hyperthyreosis. She started to feel symptoms of hyper-metabolism four months prior to hospitalization. At that time she was admitted in regional hospital and had gastroenterological examination because of diarrhea. Crohn’s disease was diagnosed and therapy started. At the same time, thyrosupressive therapy started. She had a history of hyperthyreosis thirteen years ago, duodenal hemorrhage ulcer, hyp...

Myxoid adrenocortical adenoma is a rare adenoma originated from adrenal cortex. A 51 years old male patient was admitted to our hospital due to hypertension and hypokalemia. He has a long history of nonregulated hypertension despite multiple antihypertensive medications. Hypokalemia was detected in last two years with potassium levels around 3.0 mmol/l on high supplementation dose up to 10–16 g of KCl/day. He is obese in the past 10 years. His family history was positive...

Background: Thyroid function regulates a wide array of metabolic parameters and significantly affects lipoprotein metabolism. Subclinical hypothyroidism (SCH) is the most common thyroid disorder, with a prevalence up to 10% in adult populations. Subclinical hypothyroidism is defined as mild elevation in thyroid stimulating hormones (TSH) in presence of normal free thyroxine (fT4) and free triiodothyronine (fT3). This mild elevation of serum TSH is caused by a minor initial dec...

Background: Ectopic Cushing’s syndrome (ECS) frequently represents a diagnostic challenge due to its complex clinical presentation.Case presentation: A 57-year-old male presented with typical Cushingoid appearance, high adrenocorticotropic hormone (ACTH) level (138.3 pg/ml), lack of cortisol circadian rhythm and suppression in overnight 1 mg dexamethasone suppression test (DST) (1374 nmol/l). Great daily fluctuation of serum cortisol levels from ver...

Background: Thyroid hormones have regulatory effect on serotonin and noradrenaline and thyroid dysfunction is closely linked to some mental disorders. Besides depression and anxiety, and increased risk for suicide is demonstrated in patients with Graves’ disease (GD).The aim: of our research was to determine the symptomatology of depression in patients with hyperthyroidism and Graves’ orbitopathy (GO) and compare it with hyperthyroid patients w...

Primary adrenal insufficiency (PAI) is uncommon in pregnancy. Women with PAI have reduced fertility and parity. If unrecognized or untreated during pregnancy PAI increases risk for maternal and foetal morbiditiy and mortality. Majority of women diagnosed before conception and appropriately treated, have uneventful pregnancies, with increased risk of cesarean section (CS) and preterm delivery.We report a 38-year-old woman with PAI during first spontaneus ...

Pseudohypoparathyroidism type 1a (PHP1a) is disorder characterised by resistance to the biological actions of circulating parathyroid hormone (PTH) along with typical features of Albright’s hereditary osteodystrophy (AHO). Tissue-specific imprinting of GNAS gene results in complete resistance to PTH in renal proximale tubule, but skeletal responsiveness to PTH appears intact, since Gαs is biallelically expressed in human bones. The objective of this study was to dete...